Neuropeptide Y Receptor Inhibitors

NPY Y₁ receptor

NPY Y₂ receptor, IC₅₀: 15±3 nM

rNPY Y₁ receptor, Ki: 1.1 nM

NPY Y₁ receptor

NPY Y₄ receptor

NPY Y₅ receptor

NPY Y₅ receptor

NPY Y₂ receptor

hNPFF1R, Ki: 58 nM

hNPFF2R, Ki: 75 nM

NPY Y₁ receptor

NPY Y₅ receptor

hY₁ receptor, IC₅₀: 530 nM

hY₂ receptor, IC₅₀: >500 nM

hY₄ receptor, IC₅₀: 51 nM

hY₅ receptor, IC₅₀: 0.24 nM

NPY Y₂ receptor

hNPFF1R, Ki: 58 nM

hNPFF2R, Ki: 75 nM

NPY Y₂ receptor, IC₅₀: 19 nM

human Y₂ receptor, pIC₅₀: 7.0
rat Y₂ receptor, pIC₅₀: 7.1

hY₁ receptor, Ki: 16032 nM

hY₅ receptor, Ki: 8 nM

NPY Y₂ receptor, IC₅₀: 199 nM

NPY Y₅ receptor

NPY Y₅ receptor

NPY Y₁ receptor, Kd: 1 nM

NPY Y₂ receptor, Kd: 670 nM

NPY Y₅ receptor, IC₅₀: 0.85 nM

NPY Y₅ receptor

NPY Y₁ receptor

NPY Y₁ receptor

NPY Y₁ receptor, Ki: .19 nM

hY₁ receptor, IC₅₀: 530 nM

hY₂ receptor, IC₅₀: >500 nM

hY₄ receptor, IC₅₀: 51 nM

hY₅ receptor, IC₅₀: 0.24 nM

NPY Y₂ receptor

NPY Y₁ receptor

NPY Y₄ receptor

human Y₂ receptor, pIC₅₀: 8.07
rat Y₂ receptor, pIC₅₀: 8.22
mouse Y₂ receptor, pIC₅₀: 8.21

hY₅ receptor, Ki: 1.5 nM

NPY Y₁ receptor

NPY Y₄ receptor

NPY Y₅ receptor

NPY Y₁ receptor, Kd: 1.0 nM

NPY Y₂ receptor, Kd: 670 nM

NPY Y₂ receptor

hY₁ receptor, Ki: 1.4 nM
rNPY Y₁ receptor, Ki: 1.8 nM

human Y₂ receptor, Ki: >10000 nM

hY₄ receptor, Ki: 620 nM

hY₅ receptor, Ki: 6000 nM

NPY Y₄ receptor, IC₅₀: 2.8 μM
NPY Y₄ receptor, Kb: 300-400 nM